I have simelar issues on my system. AMD 5800X3D, 32gb gskill mem, RTX 4090 and some samsung M.2 drives.
What i experience, is the mouse freezes on startup for around 10ish seconds. Same happends if im about to open random programs. I have had total freeze to, where i need to hit the power button to restart the computer after opening a program or game. This also cause screen freeze.
How ever, i dont have this issue on my Intel laptop running the same Image. So i start to belive it might be an issue with AMD setups. This is an x570 board.